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Fibronectin glomerulopathy

2 OMIM references -
1 associated gene
10 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

Familial melanoma

8 OMIM references -
6 associated genes
12 signs/symptoms

Fibronectin glomerulopathy

Familial melanoma

FN1	(UniProt - OMIM)		CDK4	(UniProt - OMIM)
			CDKN2A	(UniProt - OMIM)
			CDKN2B	(UniProt - OMIM)
			CDKN2D	(UniProt - OMIM)
			MC1R	(UniProt - OMIM)
			TERT	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FN1	(0.63)	CDKN2A

Citations in the biomedical literature:

Fibronectin glomerulopathy		Familial melanoma
	Synonym(s): - GFND - Glomerulopathy with fibronectin deposits		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare renal disease		Classification (Orphanet): - Rare eye disease - Rare genetic disease - Rare oncologic disease - Rare skin disease

	Classification (ICD10): - Diseases of the genitourinary system -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 8 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Fibronectin glomerulopathy		Familial melanoma
	Very frequent - Chronic arterial hypertension - Edema of the legs / lower limbs - Functional anomalies of the kidney and the urinary tract - Hematuria / microhematuria - Nephrotic syndrome - Proteinuria - Renal failure - Renal glomerular defect / glomerulopathy Occasional - Intracranial / cerebral / meningeal hemorrhage		Very frequent - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Melanoma Frequent - Anomalies of the lymphatic system - Dry / squaly skin / exfoliation - Excessive freckling - Hair and scalp anomalies Occasional - Breast neoplasm / tumor / carcinoma / cancer - Estomach / gastric neoplasm / tumor / carcinoma / cancer - Extrapyramidal syndrome - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Retinopathy